Three of Louisville's opponents this season did make the top 25.
The defending champion Florida State Seminoles are No. 1. Louisville plays FSU Oct. 30.
Clemson is ranked 16th. The Tigers host the Cards on Oct. 11.
Notre Dame is 17th. The Irish host the Cards on Nov. 22.
Eight SEC teams earned spots in the Preseason AP Top 25. Kentucky will play four of those teams this year.