LOUISVILLE, Ky. (WDRB) — Some people are predicting this will be the weekend of considerable chaos in college football.

Undefeated Washington on the road at formidable Utah. Undefeated Clemson on the road at proud and desperate Florida State. Unbeaten West Virginia visits Oklahoma State.

Unbeaten Baylor at really, really desperate Texas. Michigan on the road against the worst Michigan State team in decades. And unbeaten Nebraska at formidable Wisconsin.

Somebody has to lose, right?

Perhaps a couple of somebodys?

Louisville should not be one of those somebodys. The Cards are favored by 32 1/2 at Virginia. It’s the fourth time this season Louisville has been favored by 30 or more. It’s the eighth straight game Louisville has been favored — by an average of 22 points.

On to the weekend forecast

Louisville at Virginia

The Story Line: Three days before the great reveal of the College Football Playoff poll, the game plan for the Cardinals is simple: Win and win with gusto.

The Question: The Cavaliers beat the Cardinals two years ago in Charlottesville. They played them within a touchdown last season. Can they keep it close again?

The Crazy Stat: Cards are first in ACC in total offense, averaging more than 600 yards. The Cavaliers are last in the league in total defense, giving up 456 per game. I think we know the answer to The Question.

The Coverage: Noon, ABC/ESPN2, Allen Bestwick, Mike Bellotti, Kris Budden. Mike Lacett and Rick Bozich for WDRB.

The Point Spread: Louisville by 32 1/2.

The Picks: Eric Crawford Louisville 48, Virginia 17; Rick Bozich Louisville 52, Virginia 14; Katie George Louisville 45, Virginia 17; Mike Lacett Louisville 42, Virginia 6.

Kentucky at Missouri

The Story Line: The improving Wildcats can essentially insure their bowl eligibility by winning their fourth Southeastern Conference game and fifth overall against the struggling Tigers, who lost to Middle Tennessee at home last weekend.

The Question: Can quarterback Stephen Johnson continue to show the improved decision-making and performance he showed against Mississippi State?

The Crazy Stat: Nobody in the SEC gives up more yards than Missouri, which has surrendered 460 per game.

The Coverage: Noon, SEC Network. Tom Hart, Andre Ware, Cole Qubelic

The Point Spread: Missouri by 6.

The Picks: Crawford Missouri 24, UK 21; Bozich UK 20, Missouri 17; George UK 35, Missouri 24; Lacett Missouri 24, Kentucky 17.

Maryland at Indiana

The Story Line: The Hoosiers’ offense has disappeared the last three weeks. It needs to return against the Terrapins.

The Question: Will coach Kevin Wilson shake up his lineup after the Hoosiers scored only 17, 22 and 14 the last three Saturdays?

The Crazy Stat: Indiana has the most improved defense in the Big Ten, limiting opponents to about 100 fewer yards per game than last season.

The Coverage: 3:30 p.m., ESPNU, Eamon McAnaney, John Congemi; Eric Crawford and Katie George for WDRB.

The Point Spread: Indiana by 3 1/2.

The Picks: Crawford IU 28, Maryland 21; Bozich Maryland 28, IU 21; George Maryland 28, IU 17; Lacett Indiana 21, Maryland 17.

WKU at Florida Atlantic

The Story Line: The Hilltoppers are in prime position for their first three-game winning streak this season against an FAU team that has lost six straight.

The Question: Will the absence of halfback Anthony Wales for the first half affect WKU’s offensive flow?

The Crazy Stat: Mike White’s touchdown/interception of 20-to-5 reflects the solid work that Jeff Brohm has done coaching his quarterback.

The Coverage: 3:30 p.m. WBNA, Mike Gleason and Doug Chapman.

The Point Spread: WKU by 21.

The Picks: Crawford WKU 58, FAU 24; Bozich WKU 49, FAU 24; George WKU 45, FAU 21; Lacett WKU 42, FAU 17.

Final game to pick: Clemson at Florida State. Clemson favored by 4 1/2. Crawford Clemson 28, FSU 24; Bozich Clemson 31, FSU 21; George Clemson 24, FSU 20; Lacett Clemson 34, FSU 21.

Last week: Crawford 2-3; Bozich 4-1.

Season totals: Bozich 30-10; Crawford 29-11.

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