LOUISVILLE, Ky. (WDRB) -- Indiana State Police say one of three children injured after a multi-vehicle crash that happened in Jackson County has died.

ISP says 8-year-old Mecenzie Bickel was the only child left at the hospital out of the three when she died.

According to a news release, police responded around 4 p.m. to a multi-vehicle crash on I-65 south near the 38 mile marker on Saturday, Nov. 12.

Officials say an investigation shows that a 2015 Kia Forte was traveling south on I-65 near the 38 mile marker when it slowed down for an unknown reason.

Investigators say a 2012 Dodge van traveling south swerved to avoid hitting the Kia Forte. The Dodge van was then hit in the rear by a 2004 Mercury.

Four children that were inside the Dodge van suffered injuries according to police. Bickel, a 6-year-old girl and 2-year-old boy were all airlifted to Kosair Children's Hospital to be treated for "critical life-threatening injuries." Police say a fourth child, a 4-year-old female, was taken to Kosair Children's Hospital by ambulance for treatment of non-life threatening injuries.

Authorities say the female driver of the Dodge van was taken to U of L Hospital to be treated. The extent of the woman's injuries is unknown.

The driver of the Mercury was also treated for minor injuries.

Police say alcohol and drugs are not believed to be factors in the crash.

The investigation into the crash is ongoing.

Copyright 2016 WDRB News. All rights reserved.