The Cardinals will face Northern Iowa on Saturday at 6 p.m.
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Luper dominated the second set on her way to a season-high 18 kills.
Anna DeBeer and Charitie Luper led the way for Louisville as the Cardinals are a win away from another Final Four.
With 26 wins in 30 matches, do the Cardinals look like a team that can push into their third consecutive NCAA Final Four?
The Cardinals lose three All-Americans from a team that has lost just two regular-season matches in the past two years, but still have Final Four aspirations.