The war in the Middle East has intensified Monday with attacks from Iran and Iranian-backed militias hitting Israel and Arab states. A senior Iranian official signaled that there would be no negotiations with the United States. Strikes by Israel and the United States continued in Iran and southern Lebanon in a war that began Saturday with the killing of Iranian Supreme Leader Ayatollah Ali Khamenei. Fallout from the fighting has been felt around the globe. There have been canceled flights, deadly protests and suspended shipping and stock markets.