According to the Cabinet for Health and Family Services website, both cases have been in children younger than 5 years old with unknown or unvaccinated statuses.
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The measles virus can remain in the air for up to two hours after an infected person leaves an area.
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Both Indiana and Kentucky have reported confirmed cases of the measles as vaccination rates in the states remain below national averages.
Health officials are addressing concerns about the measles after a confirmed case was reported in Frankfort.
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The adult had recently traveled internationally to an area with ongoing measles transmission.