This is the first ACC victory of the season for the Cardinals.
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The Cardinals will face a former Card in Oklahoma guard Payton Verhulst and the 11th-ranked Sooners.
Nyla Harris enters her junior seasons with high expectations for herself as a leader for Louisville.
This marks the third straight year Indiana has hosted the first and second rounds of the NCAA Tournament.
UofL will need to find its form at the right time if it wants a sixth consecutive Elite Eight appearance.
The 31 points are the most for a Cardinal this season.
The Cardinals are coming off an 86-70 home loss to No. 8 Virginia Tech.
Four different UofL players scored in double figures and the Cards forced 14 Tiger turnovers, scoring 22 points off of them, as Louisville moved to 5-0 in ACC play.
The Cardinals visit Clemson on Thursday night before facing off with No. 23 North Carolina on Sunday.
The Cardinals are 14-2 in home openers under Jeff Walz. They hope to keep seeing their scoring depth shine with so many newcomers.