LOUISVILLE, Ky. (WDRB) -- The vibe around the University of Louisville’s game against Ole Miss shifted Saturday when Rebels coach Lane Kiffin …

Season-opening college football games are always tricky calls, and the University of Louisville’s 2021 opener against Ole Miss became trickier Saturday with the jarring news that Rebels’ coach Lane Kiffin will miss the game with a breakthrough case of COVID-19.