The top-ranked Knights had a 4-point lead at halftime and then used a 22-6 burst to take control in the second half.
Both players chose Indiana, the first five-star recruits to do so, speeding up the program resurgence under sixth-year head coach Teri Moren.
Alex Cook led four players in double figures with 16 points on 7-of-9 shooting.
James "Boo" Brewer's Tigers held off a late rally to beat Trinity 46-42 to improve to 3-2 on the season.
One of the powerhouse programs will add another championship to its trophy case when the Louisville schools meet at 2 p.m. Sunday at Kroger Field in Lexington, Kentucky.
When Devonte Green starts feeling it, Archie Miller kind of steps back and lets him go.
Thanks in large part to a soft early season schedule, Indiana moved to 6-0 for the first time since the 2012-13 season with an 88-75 win over Louisiana Tech on Monday night in Bloomington.
A year after going 2-6 in Conference USA and 3-9 overall, WKU is now 7-4 on the season and 5-2 in C-USA with a home game remaining against Middle Tennessee.
The Knights will begin postseason play at 6:30 p.m. Saturday against the winner of Thursday's match between No. 7 Cedarville and No. 10-seeded Wisconsin-Parkside with a spot in the Sweet 16 on the line.