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The Kentucky Transportation Cabinet announced Tuesday the section of Main Street between between Wenzel and 2nd streets will convert to two-way traffic by the end of this week.
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Several overnight lane closures are planned this week on two Louisville bridges while crews perform maintenance on tolling equipment.
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Drivers are preparing for delays, detours and uncertainty as the Interstate 65 closure begins Monday.
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The entire conversion was initially expected to be completed by spring 2026, but Kentucky Transportation Cabinet officials now anticipate the two-way transition to start later in the summer.
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There are just 18 days until a full closure of Interstate 65 in Louisville, and Louisville Metro Police are preparing.
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The I-65 Central Corridor Improvement Project will close a large stretch of the interstate between the Watterson Expressway and downtown Louisville to replace aging bridges along the interstate.
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The Kentucky Transportation Cabinet is extending this week's overnight southbound ramp and lane closures into the weekend, with an additional northbound lane closure starting Friday, May 8.
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The joint replacement project is expected to be finished this fall.
River Road closed through January; Third Street may close intermittently during KFC Yum! Center roof work.
The traffic signals at both intersections were switched to flashing red Thursday before being replaced entirely with stop signs, creating new two-way stops.