The shooting happened in the 1400 block of South 8th Street at around 11 p.m.
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Police said all parties have been accounted for and the investigation is ongoing.
The shooting happened around 12:30 a.m. in the 1500 block of West St. Catherine Street.
LMPD spokesman John Bradley said the two showed up to University of Louisville Hospital by private means around 2:45 a.m.
Officers responded to a shooting call in the 900 block of South 36th Street just after 4:30 a.m.
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When police arrived on scene, they found two people who had been shot.
Police are working to identify two persons of interest in the shooting.