The person had multiple other health conditions that contributed to the death.
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Health officials say the risk of infection is still low, but some segments of the population may be more at risk.
Only a small number of vaccines were made available for use in Kentucky due to the low number of monkeypox cases statewide.
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According to the CDC, there has been no recorded cases of monkeypox in Kentucky so far.
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Many are concerned after Kentucky's first suspected case of monkeypox was found in a Jefferson County resident last week -- but infectious disease specialists say there's no need for panic.
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Since June 23, there have been 173 monkeypox cases reported by the CDC.