There will be no traffic allowed to I-65 North from eastbound Watterson Expressway.
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The call of a multi-vehicle crash came in about 4:12 Friday morning.
The closures are expected to start on Friday, April 21 at 11 a.m. and will continue through Sunday, April 23.
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Crews in Clarksville have shut down part of a major thoroughfare because of rising flood waters.