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Interstate 264 will be closed in both directions from the I-264/I-64 interchange at mile point 18.7 to the I-264/I-71 interchange at mile point 22.7 from 7 a.m. to 5 p.m.
LG&E and KU crews are building a new substation to add to the electricity running down US 42.
The consecutive closure is necessary for crews to safely demolish and remove the upper bridge deck as part of Phase 4.
The busy stretch of interstate is one of the most heavily traveled in Kentucky.
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The interstate is blocked between Dumesnil Street and Cane Run Road, near the Park DuValle neighborhood.
The crash happened just after 8:30 a.m. Monday.
Eastbound lanes of Interstate 264 are closed near Newburg Road after a three-vehicle crash on Sunday afternoon.