The Spring Street ramp to I-64 Westbound will be closed on Friday, June 2 from 8 a.m. to noon, weather permitting.
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The crash happened just before the evening commute on Thursday.
Crews will be working on one ramp at a time but there will be multiple ramp closures throughout the night.
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The hole in the ramp from Outer Loop to Interstate 65 South was first discovered by police Wednesday afternoon. The road was shut down to traffic shortly thereafter.