A contractor will be removing formwork and sealing concrete.
Drivers are advised to use caution if driving through "Spaghetti Junction" or take an alternate route.
The Kentucky Transportation Cabinet is hoping to make the drive through the Spaghetti Junction interchange less stressful and less dangerous for drivers.
The junction was rebuilt as part of the $2.3 billion Ohio River Bridges Project, but sporadic crashes in the area prompted state officials to make changes.
The Kentucky Transportation Cabinet said work will begin to alleviate crash concerns "before November 1."
Plans call for overhead signs at the ramp from I-64 West/I-71 South ramp to I-65 South, as well as new interstate logos on the road’s surface and new pavement markers.
The wrecks on the ramp to I065 South highlight how, even after the Kentucky spent hundreds of millions of dollars, the interchange can still be challenging.