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Officials said there is currently no estimated time for the roadway to reopen.
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Interstate 65 South will close overnight Tuesday, April 7, and Friday, April 10, as crews continue work on the second and final phase of a project to replace expansion joints on the Kennedy Bridge.
Louisville's 3rd Street "can opener" claimed another semi-truck on Tuesday.
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TRIMARC reported the multi-vehicle crash happened at 2:02 p.m. at mile marker 35.9 near I-71.