LOUISVILLE, Ky. (WDRB) – Eight days after the signature win of the Jeff Brohm era, Louisville faces the next challenge: building on it.
The 19th-ranked Cardinals are back home Saturday night to host Boston College, a team that gave them a serious scare a season ago. Last week, Louisville got the attention of the college football world by going on the road and taking down No. 2 Miami — matching the highest ranked team it has ever defeated.
Now comes a challenge that’s just as tough — sustaining it.
Louisville’s defense forced four turnovers and its offensive line delivered its best performance of the season in the Miami win. But was that newfound offensive line stability a sustainable fix, or just a schematic success against an aggressive opponent?
Boston College jumped out to a 20-0 lead and led 27-10 last year before Louisville scored 21 unanswered points to escape. The Eagles’ offense has struggled for consistency in 2025 but features dangerous playmakers in wideout Lewis Bond and running back Turbo Richard, and made a quarterback change last week in hopes of a spark.
This is Homecoming for the Cards, who are 61-37 all-time in such games and 22-5 in Homecoming games at L&N Stadium.Â
It’s also the first visit to Louisville from the ACC Network’s flagship football program, ACC Huddle. The set will be located at The Alley, near L&N Stadium, and Cardinals’ coach Jeff Brohm will appear live at 10:15. Breakfast will be provided to fans while supplies last and fans can take part in exclusive giveaways including a limited-edition t-shirt.
Free parking is available in the Solea Lots (2441 S. Floyd St.) beginning at 9 a.m., with The Alley opening also at 9 a.m. (Fans will have to leave that lot once the show is over at noon.)
What to know about the game:
The Time
Saturday, Oct. 25, 2025, 7:30 p.m. ET, L&N Stadium (60,800), Louisville, Ky.
How to Watch / Listen
TV: ACC Network (Jorge Sedano play-by-play, Rodney McLeod analyst, Victoria Arlen sideline. Streaming: ESPN app
Radio: 93.9 FM The Ville, 1450 AM (Paul Rogers play-by-play, Craig Swabek analyst, Jody Demling sideline. Streaming: ESPN Radio app. Satellite: Sirius XM Ch. 133
The Line
Spread:Â Louisville is a 25.5-point favorite (DraftKings)
Over/Under:Â 54.5
Notes: Louisville is 2-4 against the spread (ATS) this season — both covers came on the road. The Cardinals are 0-2 ATS as a 25.5-point favorite or greater in 2025. Boston College is 2-5 ATS and faces its largest spread of the season. Louisville is 3-3 ATS the last six times BC has visited.
The Coaches
Louisville:Â Jeff Brohm (3rd season at U of L, 24-9; 90-53 overall)
Boston College: Bill O’Brien (2nd season at BC, 8-12; 23-20 overall)
Series History
Overall: Louisville leads 10-7. In Louisville: Louisville leads 6-2. Last Meeting: Louisville won 31-27 at BC (Oct. 25, 2024). Recent note: Louisville has won three straight in the series.
The Records
Louisville:Â 5-1 (2-1 ACC), coming off a 24-21 win at No. 2 Miami
Boston College:Â 1-6 (0-4 ACC), coming off a 17-14 loss to UConn
Players to Watch
Louisville: Quarterback Miller Moss has 916 passing yards and 7 TDs over the last three games. Wideout. Chris Bell is playing the best football of his career, with three straight 100-yard games, 638 yards and 6 TDs on the season. Running back Isaac Brown is coming off a 113-yard rushing game at Miami. Linebacker T.J. Quinn has 37 tackles and a pair of interceptions on the season. SAM linebacker Antonio Watts has three interceptions, tied for eighth-best nationally.
Boston College: Started Grayson James, a 6-3 redshirt senior, last week against UConn. He completed 16 of 28 passes for 204 yards and two touchdowns. He threw for more than 1,200 yards last season. First-year starter Dylan Lonergan has 1,394 yards and 9 TDs this season.  Wideout Lewis Bond leads the ACC in receptions, but has not caught a touchdown pass. Running back Turbo Richard has rushed for 431 yards and has 7 total touchdowns this season (5 rushing 2 receiving). Safety Omar Thornton totaled 10 tackles in last week’s loss to Connecticut the third time this season he’s had 10 or more tackles. His 6 tackles for loss rank second on the team and he’s forced two fumbles. Safety KP Price leads the team with and the ACC with 34 solo tackles.
Quick Sideline Storylines
THE HANGOVER OR TAKEOFF? – Was Miami the peak or the launchpad? The next chapter starts here. Click here to read more about Louisville’s fortunes after being ranked opponents.
HOME SWEET HOME: Louisville’s last home game, a loss to No. 24 Virginia, snapped a four-game home winning streak. The Cards are just 2-4 ATS this season overall, including 0-2 at home as big favorites.
TURNOVER TITANS:Â The Cards are tied for fifth nationally in interceptions (10). BC has thrown 6 picks this season.
DEFENSE ON A ROLL: Louisville ranks 10th nationally in fewest yards allowed per game and fifth nationally in total defense against ranked opponents.Â
BELL RINGING:Â Louisville receiver Chris Bell is establishing himself as one of the top receivers in the country. He ranks third nationally with an averÂage of 106.3 yards receiving per game and his average of 7.3 catches per game ranks fifth nationally.Â
INJURY WATCH:Â Running back Duke Watson remains out for Louisville, while defensive end Wes Bailey was listed as questionable, along with wideout Kris Hughes and others. BC is down 13 players. See a full injury report from the ACC by clicking here.
The Quote
"It was 20 to nothing. We were losing the fourth quarter. We were down by 10, and we had to fight and claw to get back. And you know, if our guys don't remember that, then there's something wrong with them.”
— Jeff Brohm, Louisville head coach, on Boston College
The Pick
Louisville 38, Boston College 14
Boston College’s passing attack could test Louisville’s secondary, but the Cardinals’ defensive momentum and big-play offense should carry the day. Still, a backdoor cover is a worry. Momentum matters, and if Louisville is serious about its postseason hopes, this is a business trip at home.
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