The Kentucky Transportation Cabinet said the left and center lanes will be closed to complete work on joint repairs between East Broadway and the Kennedy Bridge.
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Sections of River Road will be closed daily from 9 a.m. to 3 p.m. through July 21.
Street closures were released for the Mayor's Hike, Bike & Paddle that returns Memorial Day in downtown Louisville.
The first race of the annual running series, the 5K, starts at 8 a.m. at Slugger Field at Brook and East Market streets in downtown Louisville.