Officers believe the man was traveling at a high rate of speed when he lost control and was ejected from the bike.
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Lorenzo Johnson ran a red light and crashed into another vehicle, ejecting the driver and causing damage to a building.
The Jackson County Coroner's Office identified the victim as 66-year-old Kim Kaufman from Vallonia, Indiana.
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LMPD spokesperson Aaron Ellis said police responded to a crash around 2 a.m. on the Watterson Expressway at Interstate 65.