The road was extended by four miles before the bridge opened in December 2016.
The closure will allow crews from the Kentucky Transportation Cabinet to inspect, repair and update decorative lighting on the bridge.
Starting at 8 p.m. on Monday, the right lane at I-265 southbound over Shelbyville Road will close.
The closures are scheduled to start at 8 o'clock Wednesday night on the Lewis and Clark bridge.
During the lane closures, crews will perform routine maintenance on the Gene Snyder Freeway.
Since tolling began on three Ohio River bridges in late 2016, RiverLink operators have struggled to collect tolls and late fees from drivers who don’t pay.
The annual toll increase on the RiverLink bridges would be tied to inflation this year. A Kentucky board is asking for action to 'minimize' the jump that would take effect in July.
The tunnels on the Kentucky side of the Lewis & Clark Bridge are closed and will remain so for several hours while crews perform emergency maintenance after the sprinkler system went off.
A new study provides the best look to date on how much money isn't being received from drivers without a transponder for the Louisville-area toll bridges.
Lawyers for drivers who challenged RiverLink billing practices have asked a judge to reconsider her ruling.