It happened around 2:45 a.m. in the 1100 block of Canopy Court.
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Police have not said what led up to the shooting.
Police said the man was found in the 400 block of North 22nd Street.
A man was shot and killed in the Jacobs neighborhood on Saturday afternoon, according to Louisville Metro Police.
A man was shot and killed in the Shawnee neighborhood on Tuesday afternoon, according to Louisville Metro Police.
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Two men died after a shooting in Old Louisville on Monday night, according to Louisville Metro Police.