The man was identified by the Jefferson County Coroner's Office as 43-year-old Samuel Thruston.
Officers responded just after midnight to the shooting in the 6500 block of Hackel Drive, near Lower Hunters Trace.
Officers responded to a Shotspotter call in the 2400 block of Magazine Street just before 1:00 a.m.
The Jefferson County Coroner's Office said Montrez Boyington, 34, died from multiple gunshot wounds.
Detectives are working to learn what led up to the shooting and what a possible motive may have been.
It happened just after midnight in the 400 block of North 22nd Street.
It happened in the 1600 block of South 11th Street.
Police are investigating after a woman was shot and killed early Monday morning near New Cut Road in Old Louisville.
The shooting happened about 1 p.m. Tuesday, according to Louisville Metro Police.
It happened around 4:30 a.m. Monday in the 2200 block of Dumesnil Street.