Medical professionals in Kentuckiana have already seen a spike in respiratory cases like COVID and the flu, so they're warning parents to take precautions.
Norton Children's pediatrician Dr. Amael Shalash said there have been more than a thousand flu cases system-wide this month.
Officials said neither child had been immunized against the viruses that caused their deaths.
Flu cases are up over 15% while COVID-19 cases are down around 5% in Kentucky, according to data from the last week of 2023.
They are blaming air quality issues and students' return to classes for the spike.
The death toll already meets the prior record for the highest number of pediatric influenza deaths ever reported in Kentucky in a single flu season.
So far, no children have died from the flu in Indiana.
Doctors said the best ways to avoid getting the flu include getting the vaccine, cleaning frequently-touched objects and washing your hands often.
COVID-19 booster shots will also be available.
The flu is making its rounds again in Kentucky and southern Indiana and doctors want you to get the shot.