Two people were flown to Louisville hospitals with life-threatening injuries.
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The pursuit ended in a crash with a Crothersville, Indiana K-9 unit.
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According to court documents, 26-year-old Richard Doneghy was arrested by Kentucky Sate Police just before 2:30 p.m.
Police have not said why they were pursuing the car.
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A La Grange man is accused of leading police on a vehicle chase and leaving one woman seriously injured, all while high on drugs.
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The suspect's vehicle hit three other vehicles before catching fire, according to police.
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Police say a chase that started in Bullitt County ended with a car crashing into a Boston, Kentucky home -- and a suspect still on the loose.
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According to an arrest report, the incident began late Tuesday night, at the Circle K on Preston Highway, near East Manslick Road.
No one was injured during the pursuit.
The 22-year-old man is facing a list of charges.