The Louisville health department reports more than 700 flu cases since September.
Health experts said the best way top protect yourself and those around you is by getting vaccinated.
Medical professionals in Kentuckiana have already seen a spike in respiratory cases like COVID and the flu, so they're warning parents to take precautions.
Indiana health officials announced these are the first flu related deaths this flu season.
Last season, the CDC estimated at least 26 million people suffered from the flu.
The death toll already meets the prior record for the highest number of pediatric influenza deaths ever reported in Kentucky in a single flu season.
Doctors said the best ways to avoid getting the flu include getting the vaccine, cleaning frequently-touched objects and washing your hands often.
According to the agency, 82 Indiana residents died in the 2021-22 season. Residents are encouraged to get the flu vaccine.
Pediatricians are urging parents to get their children vaccinated against the flu by the end of October.
No appointments are necessary.