Police said the driver of the vehicle is in good condition while the passenger, who was taken to Norton Children's Hospital, is in serious condition.
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It happened just before 7:30 a.m. Saturday on the Buechel Bypass at Plaza Avenue.
Officers provided aid until EMS arrived to transport the man to UofL Hospital.
Louisville Metro Police Department responded around 3:45 a.m. to the 4600 block of Hendrik Drive off South Hurstbourne Parkway and found the female with a gunshot wound to the leg.
LMPD's Sixth Division is investigating.
LMPD's Sixth Division is investigating the shooting.
A pickup truck crashed into an apartment building in the Bashford Manor neighborhood on Thursday, according to Louisville Metro Police.
Corey Robinson, division commander for LMPD's Sixth Division, who is a father himself, said this case hits home.
The child was taken to Norton Children's Hospital in downtown Louisville with injuries not thought to be life threatening, according to police.
Officers with the LMPD's Sixth Division responded to a reported shooting just before 7:30 p.m. at Preston Highway and Grade Lane.