Rolling traffic stops will be in effect for both northbound and southbound lanes.
The crash was reported just before 6 p.m. Thursday in the northbound lanes of I-71, just before I-264.
The work is part of "The I-Move Kentucky" project.
Kentucky State Police say the problems started about 11 a.m. Saturday.
It happened around 9:30 p.m. Wednesday on southbound I-71 near Pendleton and involved several vehicles, including a tanker truck carrying liquid hydrogen that burst into flames.
Drivers are asked to use caution while driving in the area.
LOUISVILLE, Ky. (WDRB) - All lanes on part of I-71 southbound have reopened.
Shorter closures could happen though the weekend.
A caller witnessed the theft in Bedford and followed the suspects, according to police. That's when police say one of the suspects opened fire.
The crash took place just before 1 p.m. on Monday.